Light-Armed Nitric Oxide-Releasing Micromotor In Vivo.
Nano Lett
; 24(40): 12452-12460, 2024 Oct 09.
Article
in En
| MEDLINE
| ID: mdl-39319576
ABSTRACT
The delivery of NO at a high spatiotemporal precision is important but still challenging for existing NO-releasing platforms due to the lack of precise motion control and limited biomedical functions. In this work, we propose an alternative strategy for developing the light-armed nitric oxide-releasing micromotor (LaNorM), in which a main light beam was employed to navigate the microparticle and stimulate NO release and an auxiliary light beam was used to cooperate with the released NO to act as a remotely controlled scalpel for cell separation. Benefiting from the advantages of fully controlled locomotion, photostimulated NO release, and microsurgery ability at the single-cell level, the proposed LaNorM could enable a series of biomedical applications in vivo, including the separation of flowing emboli, selective removal of a specific thrombus, and inhibition of thrombus growth, which may provide new insight into the precise delivery of NO and the treatment of cardiovascular diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombosis
/
Light
/
Nitric Oxide
Limits:
Animals
/
Humans
Language:
En
Journal:
Nano Lett
/
Nano lett
/
Nano letters
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States