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Advances in Understanding and Management of IgG4-Related Ophthalmic Disease.
Lai, Kenneth Ka Hei; Ang, Terence Wee Xiang; Cheuk, Wah; Kwok, Angie; Lin, Ming; Lustig, Yael; Selva, Dinesh; Ben Simon, Guy; Xing, Yue; Xu, Zhi Hui; Yang, Hua Sheng; Chong, Kelvin Kam Lung; Yuen, Hunter Kwok Lai.
Affiliation
  • Lai KKH; Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR.
  • Ang TWX; The University of Adelaide, Adelaide, South Australia, Australia.
  • Cheuk W; Department of Pathology, Queen Elizabeth Hospital, Hong Kong SAR.
  • Kwok A; Department of Pathology, Queen Elizabeth Hospital, Hong Kong SAR.
  • Lin M; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
  • Lustig Y; The Goldschleger Eye Institute, Sheba Medical Center, Tel HaShomer, Israel.
  • Selva D; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Ben Simon G; The Goldschleger Eye Institute, Sheba Medical Center, Tel HaShomer, Israel.
  • Xing Y; Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
  • Xu ZH; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
  • Yang HS; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
  • Chong KKL; Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR; Hong Kong Eye Hospital, Hong Kong SAR; Eye Centre, The Chinese University of Hong Kong M
  • Yuen HKL; Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR; Hong Kong Eye Hospital, Hong Kong SAR. Electronic address: yuenkl1@ha.org.hk.
Asia Pac J Ophthalmol (Phila) ; : 100101, 2024 Sep 24.
Article in En | MEDLINE | ID: mdl-39326526
ABSTRACT
Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is an emerging, immune-mediated fibroinflammatory orbital disease, characterized by tumefactive lesions with noticeable IgG4+ plasma cell infiltration and distinctive pathohistological features. This disease is often associated with elevated serum IgG4 concentrations. IgG4-ROD may affect any ophthalmic tissues, particularly the lacrimal gland, extraocular muscles, and trigeminal nerves. Although the exact pathogenic role of IgG4 antibodies remains unclear, B-cell depleting agents have been reported to be an effective treatment. The diverse clinical manifestations of IgG4-ROD complicate diagnosis, and without prompt treatment, visual-threatening complications such as optic neuropathy may arise. Recent advances in understanding and managing IgG4-ROD have revolutionized the diagnosis and treatment of this emerging disease. This review article aims to provide a comprehensive overview of the latest advancements in the field of IgG4-ROD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Asia Pac J Ophthalmol (Phila) Year: 2024 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Asia Pac J Ophthalmol (Phila) Year: 2024 Document type: Article Country of publication: United States