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Unveiling the Impact of Human Herpesviruses-Associated on CNS Infections: An Observational Study.
Barrionuevo, Caio Cesar L B; Baptista, Pedro P A; da Silva, Ewerton F; da Silva, Bernardo M; Goulart, Cássia da L; de Melo, Sabrina A; da Silva, Valderjane A; de Souza, Lara Laycia A; Monte, Rossicleia L; Almeida-Val, Fernando F; Feitoza, Pablo Vinícius S; Bastos, Michele de S.
Affiliation
  • Barrionuevo CCLB; Programa de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
  • Baptista PPA; Faculdade de Educação Física e Fisioterapia, Universidade Federal do Amazonas, Manaus 69060-001, Brazil.
  • da Silva EF; Gerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.
  • da Silva BM; Programa de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
  • Goulart CDL; Programa de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
  • de Melo SA; Gerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.
  • da Silva VA; Programa de Pós-Graduação em Ciências da Saúde (PPGCIS), Manaus 69020-180, Brazil.
  • de Souza LLA; Programa de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
  • Monte RL; Gerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.
  • Almeida-Val FF; Programa de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
  • Feitoza PVS; Departamento de Clínica Cirúrgica, Faculdade de Medicina, Universidade Federal do Amazonas, Manaus 69020-170, Brazil.
  • Bastos MS; Gerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.
Viruses ; 16(9)2024 Sep 09.
Article in En | MEDLINE | ID: mdl-39339913
ABSTRACT
Human Herpesviruses (HHVs) play a significant role in neurological diseases such as encephalitis and meningitis, adding significant morbidity. This study aims to retrospectively analyze the effect of HHVs on patients with neurological symptoms, focusing on the Herpesviridae family's contributions to central nervous system (CNS) infections.

METHODS:

This retrospective cohort study included 895 patients suspected of viral CNS infections, utilizing molecular diagnosis via qPCR to identify HHVs in cerebrospinal fluid (CSF) samples. This was conducted at a reference tertiary care hospital for infectious diseases in the western Brazilian Amazon from January 2015 to December 2022, focusing on the Herpesviridae family's clinical repercussions and of Cytomegalovirus in CNS infections.

RESULTS:

The findings revealed that 7.5% of the analyzed samples tested positive for HHVs, with Human Cytomegalovirus (HCMV) and Epstein-Barr Virus (EBV) being the most prevalent. A significant association was found between HHVs and neurological diseases such as encephalitis and meningitis, especially among people living with HIV/AIDS (PLWHA), highlighting the opportunistic nature of these viruses. The study underscores the critical role of CSF analysis in diagnosing CNS infections and the complexity of managing these infections in HIV patients due to their immunocompromised status.

CONCLUSIONS:

The results emphasize the need for comprehensive diagnostic approaches and tailored treatment strategies for CNS infections in immunocompromised individuals. The study calls for ongoing research and advancements in clinical practice to improve patient outcomes facing CNS infections, particularly those caused by HHVs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Herpesviridae Infections / Herpesviridae Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: America do sul / Brasil Language: En Journal: Viruses Year: 2024 Document type: Article Affiliation country: Brazil Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Herpesviridae Infections / Herpesviridae Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: America do sul / Brasil Language: En Journal: Viruses Year: 2024 Document type: Article Affiliation country: Brazil Country of publication: Switzerland