Structural Perspective of the Double-Stranded RNA Transport Mechanism by SID-1 Family Proteins.
Biol Pharm Bull
; 47(10): 1610-1615, 2024.
Article
in En
| MEDLINE
| ID: mdl-39358240
ABSTRACT
The systemic RNA interference defective 1 (SID-1) family proteins are putative double-stranded RNA (dsRNA) transporters. Two mammalian homologs, SIDT1 and SIDT2 have been linked to many functions such as innate immune responses, microRNA uptake and lysosomal degradation of RNA/DNA whereas Caenorhabditis elegans SID-1 is essential for systemic RNA interference. However, dsRNA uptake mechanism is largely unknown. In this review, we discuss our current understanding of the molecular functions of SID-1 family proteins at a structure level, which highlights recent structural studies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA, Double-Stranded
/
Caenorhabditis elegans Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Biol Pharm Bull
Journal subject:
BIOQUIMICA
/
FARMACOLOGIA
Year:
2024
Document type:
Article
Country of publication:
Japan