Invited Commentary: Thirty-five Years of Leaky Vaccines.
Am J Epidemiol
; 2024 Oct 02.
Article
in En
| MEDLINE
| ID: mdl-39359003
ABSTRACT
Over the past 35 years, the term "leaky vaccine" has gained widespread use in both mathematical modeling and epidemiologic methods for evaluating vaccines. Here we present a short history as we recall it of how the term was coined in the context of the history of sporozoite malaria vaccines that were thought to be possibly leaky in the 1980s. We draw a contrast with the all-or-none vaccine mechanism and review a few consequences for study design and population level effects. We invite readers to contribute information covering the time period preceding our memories in the 1980s as we may have overlooked something.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Am J Epidemiol
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States