Effects of Apelin-13 on auditory system in STZ-induced diabetic rats.
Neurosci Lett
; : 137996, 2024 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-39362462
ABSTRACT
AIM:
Damage to the auditory pathways is one of the complications of diabetes. The aim of this study was to investigate the potential therapeutic effects of apelin-13 in the auditory pathways of rats with experimentally induced diabetes by examining its effect on auditory brainstem responses, cochlear oxidative stress and inflammatory cytokines.METHODS:
Thirty-two male Wistar albino rats were divided into four groups sham control, diabetes, apelin and diabetesâ¯+â¯apelin. A single dose of 45â¯mg/kg streptozotocin (STZ) was administered to induce diabetes. The apelin group received 50⯵g/kg apelin-13 for seven days intraperitoneally (ip). At the end of the apelin and STZ applications auditory brainstem responses (ABR) was recorded. At the end of the experiment, cochlea was removed and biochemical analyzes were performed.RESULTS:
In ABR recordings, the latencies of wave V in diabetic group were observed to be longer than those of the control, with the apelin treatment exhibiting a partial reversal of this situation, particularly at specific frequencies and intensity levels. Apelin treatment leads to a significant increase in total antioxidant status (TAS) and a reduction in total oxidant status (TOS) and oxidative stress index (OSI) in cochlea compared to diabetic groups. The levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-beta (IL-1 beta) in cochlear tissue were found to be significantly reduced in the apelin-treated group compared to the diabetic group.CONCLUSION:
Apelin-13 may have a protective effect on the auditory system and may be proposed as a potential new therapeutic strategy for the management diabetic auditory impairment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Neurosci Lett
Year:
2024
Document type:
Article
Country of publication:
Ireland