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Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin, Soumitra; Montoya, Marhiah C; Wang, Xiaoyu; Zarnowski, Robert; Andes, David R; Meyers, Marvin J; Williams, Noelle S; Krysan, Damian J.
Affiliation
  • Guin S; Department of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri, USA.
  • Montoya MC; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
  • Wang X; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.
  • Zarnowski R; Department of Medicine, Section of Infectious Disease, University of Wisconsin, Madison, Wisconsin, USA.
  • Andes DR; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA.
  • Meyers MJ; Department of Medicine, Section of Infectious Disease, University of Wisconsin, Madison, Wisconsin, USA.
  • Williams NS; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA.
  • Krysan DJ; Department of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri, USA.
Antimicrob Agents Chemother ; : e0130124, 2024 Oct 04.
Article in En | MEDLINE | ID: mdl-39365066
ABSTRACT
Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives of the malarial drug mefloquine have broad-spectrum antifungal activity including difficult-to-treat molds and endemic fungi. Pharmacokinetic and efficacy studies of NSC-4377 indicate that it penetrates the central nervous system and is active against Candida auris in vivo. These data strongly support the further development of mefloquine analogs as a potentially new class of antifungal molecules.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Antimicrob Agents Chemother Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Antimicrob Agents Chemother Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States