Nanorobot Swarms Made with Laser-Induced Graphene@Fe3O4 Nanoparticles with Controllable Morphology for Targeted Drug Delivery.

ABSTRACT

Magnetic nanorobot swarms can mimic group behaviors in nature and can be flexibly controlled by programmable magnetic fields, thereby having great potential in various applications. This paper presents a novel approach for the rapid and large-scale processing of laser-induced graphene (LIG) @Fe3O4-based-nanorobot swarms utilizing one-step UV laser processing technology. The swarm is capable of forming a variety of reversible morphologies under the magnetic field, including vortex-like and strip-like, as well as the interconversion of these, demonstrating high levels of controllability and flexibility. Moreover, the maximum forward motion speed of the nanorobot swarm is up to 2165 µm/s, and the drug loading and release ability of such a nanorobot swarm is enhanced about 50 times due to the presence of graphene, enabling the nanorobot swarm to show rapid and precise targeted drug delivery. Importantly, by controllable morphology transformation to conform to the complicated requirements for the magnetic field, the drug-loaded swarm can smoothly pass through a width-varying zigzag channel while maintaining 96% of the initial drug-loading, demonstrating that LIG @Fe3O4 NPs-based nanorobot swarm can provide effective and controllable targeted drug delivery in complex passages.