Mimicomes: Mimicking Multienzyme System by Artificial Design.

ABSTRACT

Enzymes are widely distributed in organelles of cells, which are capable of carrying out specific catalytic reactions. In general, several enzymes collaborate to facilitate complex reactions and engage in vital biochemical processes within cells, which are also called cascade systems. The cascade systems are highly efficient, and their dysfunction is associated with a multitude of endogenous diseases. The advent of nanotechnology makes it possible to mimic these cascade systems in nature and realize partial functions of natural biological processes both in vitro and in vivo. To emphasize the significance of artificial cascade systems, mimicomes is first proposed, a new concept that refers to the artificial cascade catalytic systems. Typically, mimicomes are able to mimic specific natural biochemical catalytic processes or facilitate the overall catalytic efficiency of cascade systems. Subsequently, the evolution and development of different types of mimicomes in recent decades are elucidated exhaustedly, from the natural enzyme-based mimicomes (immobilized enzyme and vesicle mimicomes) to the nanozyme-based mimicomes and enzyme-nanozyme hybrid mimicomes. In conclusion, the remaining challenges in the design of multifunctional mimicomes and their potential applications are summarized, offering insights into their future prospects.