The role of islet autoantigen-specific T cells in the onset and treatment of type 1 diabetes mellitus.
Front Immunol
; 15: 1462384, 2024.
Article
in En
| MEDLINE
| ID: mdl-39380988
ABSTRACT
Type 1 diabetes mellitus (T1DM), a complex chronic disease with an intricate etiology and pathogenesis, involves the recognition of self-antigens by pancreatic islet autoantigen-specific T cells and plays crucial roles in both early- and late-stage destruction of beta cells, thus impacting disease progression. Antigen-specific T cells regulate and execute immune responses by recognizing particular antigens, playing broad roles in the treatment of various diseases. Immunotherapy targeting antigen-specific T cells holds promising potential as a targeted treatment approach. This review outlines the pathogenesis of diabetes, emphasizing the pivotal role of pancreatic islet autoantigen-specific T cells in the progression and treatment of T1DM. Exploring this avenue in research holds promise for identifying novel therapeutic targets for effectively managing diabetes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoantigens
/
T-Lymphocytes
/
Islets of Langerhans
/
Diabetes Mellitus, Type 1
Limits:
Animals
/
Humans
Language:
En
Journal:
Front Immunol
/
Front. immunol
/
Frontiers in immunology
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Switzerland