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Detection of dengue virus serotype 4 in Panama after 23 years without circulation.
Chen-Germán, María; Araúz, Dimelza; Aguilar, Celestino; Vega, Melanie; Gonzalez, Claudia; Gondola, Jessica; Moreno, Lourdes; Cerezo, Lizbeth; Franco, Leticia; Mendez-Rico, Jairo; Pascale, Juan Miguel; López-Vergès, Sandra; Martínez, Alexander A; Moreno, Brechla.
Affiliation
  • Chen-Germán M; Modular Specialized Laboratory, Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama.
  • Araúz D; Modular Specialized Laboratory, Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama.
  • Aguilar C; Department of Genomics and Proteomics, Gorgas Memorial Institute of Health Studies, Panama City, Panama.
  • Vega M; Department of Microbiology and Immunology, University of Panama, Panama City, Panama.
  • Gonzalez C; Modular Specialized Laboratory, Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama.
  • Gondola J; Department of Genomics and Proteomics, Gorgas Memorial Institute of Health Studies, Panama City, Panama.
  • Moreno L; Department of Microbiology and Immunology, University of Panama, Panama City, Panama.
  • Cerezo L; Department of Genomics and Proteomics, Gorgas Memorial Institute of Health Studies, Panama City, Panama.
  • Franco L; National Department of Epidemiology, Ministry of Health, Panama City, Panama.
  • Mendez-Rico J; National Department of Epidemiology, Ministry of Health, Panama City, Panama.
  • Pascale JM; Infectious Hazard Management Unit, Health Emergencies Department, Pan American Health Organization, Washington, DC, United States.
  • López-Vergès S; Infectious Hazard Management Unit, Health Emergencies Department, Pan American Health Organization, Washington, DC, United States.
  • Martínez AA; Department of Microbiology and Immunology, University of Panama, Panama City, Panama.
  • Moreno B; Gorgas Memorial Institute of Health Studies, Panama City, Panama.
Front Cell Infect Microbiol ; 14: 1467465, 2024.
Article in En | MEDLINE | ID: mdl-39411321
ABSTRACT
Panama is a country with endemic Dengue virus (DENV) transmission since its reintroduction in 1993. The four serotypes have circulated in the country and the region of the Americas, however, DENV-4 confirmed autochthonous cases have not been identified since 2000, despite its circulation in neighboring countries. Here, we report DENV-4 detection in Panama in the last four-month period of 2023 with co-circulation of the other serotypes, this was associated with a peak of dengue cases during the dry season even though most dengue outbreaks are described in the rainy season. Complete genomes of DENV-4 allowed us to determine that cases were caused by DENV-4 genotype IIb, the same genotype as 23 years ago, with high similarity to DENV-4 sequences circulating in Nicaragua and El Salvador during 2023. This report shows the importance of maintaining serotype and genotype surveillance for early detection of new variants circulating in the country.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phylogeny / Genome, Viral / Dengue / Dengue Virus / Serogroup / Genotype Limits: Humans Country/Region as subject: America central / Nicaragua / Panama Language: En Journal: Front Cell Infect Microbiol Year: 2024 Document type: Article Affiliation country: Panama Country of publication: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phylogeny / Genome, Viral / Dengue / Dengue Virus / Serogroup / Genotype Limits: Humans Country/Region as subject: America central / Nicaragua / Panama Language: En Journal: Front Cell Infect Microbiol Year: 2024 Document type: Article Affiliation country: Panama Country of publication: Switzerland