Modification of 3-hydroxy-3-methylglutaryl coenzyme A reductase immunoinhibition curves by substrates and inhibitors. Evidence for conformational changes leading to alterations in antigenicity.

Rogers, D H; Rudney, H

Rogers, D H; Rudney, H.

J Biol Chem ; 257(18): 10650-8, 1982 Sep 25.

Article in En | MEDLINE | ID: mdl-6179943

Subject(s)

Epitopes/analysis; Hydroxymethylglutaryl CoA Reductases/metabolism; Microsomes, Liver/enzymology; Animals; Antibodies; Antigen-Antibody Complex; Hydroxymethylglutaryl CoA Reductases/immunology; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunodiffusion; Immunoelectrophoresis; Kinetics; Lovastatin; Male; Naphthalenes/pharmacology; Rats; Rats, Inbred Strains

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Hydroxymethylglutaryl CoA Reductases / Epitopes Limits: Animals Language: En Journal: J Biol Chem Year: 1982 Document type: Article Country of publication: United States

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