Mechanism of inhibition of microsomal drug metabolism by imidazole.

Hajek, K K; Cook, N I; Novak, R F

Hajek, K K; Cook, N I; Novak, R F.

J Pharmacol Exp Ther ; 223(1): 97-104, 1982 Oct.

Article in En | MEDLINE | ID: mdl-7120133

Subject(s)

Imidazoles/pharmacology; Microsomes, Liver/enzymology; Mixed Function Oxygenases/antagonists & inhibitors; Oxidoreductases/antagonists & inhibitors; Pharmaceutical Preparations/metabolism; Animals; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Cytochrome P-450 Enzyme System/metabolism; In Vitro Techniques; Male; Microsomes, Liver/drug effects; Nitroanisole O-Demethylase/antagonists & inhibitors; Oxidation-Reduction; Oxidoreductases, N-Demethylating/antagonists & inhibitors; Rabbits; Spectrophotometry

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Microsomes, Liver / Pharmaceutical Preparations / Mixed Function Oxygenases / Imidazoles Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1982 Document type: Article Country of publication: United States

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