Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias.

Trottier, Y; Lutz, Y; Stevanin, G; Imbert, G; Devys, D; Cancel, G; Saudou, F; Weber, C; David, G; Tora, L

Trottier, Y; Lutz, Y; Stevanin, G; Imbert, G; Devys, D; Cancel, G; Saudou, F; Weber, C; David, G; Tora, L.

Affiliation

Trottier Y; Institut de Génétique et de Biologie Moléculaire et Cellulaire (GBMC), CNRS, INSERM, Illkirch, France.

Nature ; 378(6555): 403-6, 1995 Nov 23.

Article in En | MEDLINE | ID: mdl-7477379

Subject(s)

Cerebellar Ataxia/metabolism; Glutamine/metabolism; Huntington Disease/metabolism; Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Adult; Antibodies, Monoclonal/immunology; Ataxin-1; Ataxins; Blotting, Western; Cell Line; Cerebellar Ataxia/immunology; Cerebellar Ataxia/pathology; DNA-Binding Proteins/metabolism; Female; Glutamine/immunology; Humans; Huntingtin Protein; Huntington Disease/immunology; Huntington Disease/pathology; Male; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/immunology; Nuclear Proteins/chemistry; Nuclear Proteins/immunology; TATA-Box Binding Protein; Transcription Factors/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Cerebellar Ataxia / Huntington Disease / Glutamine / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Nature Year: 1995 Document type: Article Affiliation country: France Country of publication: United kingdom

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