The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.

Kvassman, J O; Lawrence, D A; Shore, J D

Kvassman, J O; Lawrence, D A; Shore, J D.

Affiliation

Kvassman JO; Henry Ford Health Sciences Center, Division of Biochemical Research, Detroit, Michigan 48202-3450, USA.

J Biol Chem ; 270(46): 27942-7, 1995 Nov 17.

Article in En | MEDLINE | ID: mdl-7499270

Subject(s)

Plasminogen Activator Inhibitor 1/chemistry; Protein Structure, Secondary; Amino Acid Sequence; Binding Sites; Drug Stability; Hot Temperature; Humans; Hydrogen-Ion Concentration; Kinetics; Mathematics; Models, Structural; Molecular Sequence Data; Peptide Fragments/chemistry; Plasminogen Activator Inhibitor 1/metabolism; Plasminogen Activator Inhibitor 1/pharmacology; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Recombinant Proteins/pharmacology; Thermodynamics; Trypsin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Structure, Secondary / Plasminogen Activator Inhibitor 1 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 1995 Document type: Article Affiliation country: United States Country of publication: United States

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