Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506.

Iwasaki, K; Shiraga, T; Matsuda, H; Nagase, K; Tokuma, Y; Hata, T; Fujii, Y; Sakuma, S; Fujitsu, T; Fujikawa, A

Iwasaki, K; Shiraga, T; Matsuda, H; Nagase, K; Tokuma, Y; Hata, T; Fujii, Y; Sakuma, S; Fujitsu, T; Fujikawa, A.

Affiliation

Iwasaki K; Department of Pharmacokinetics and Drug Metabolism, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

Drug Metab Dispos ; 23(1): 28-34, 1995 Jan.

Article in En | MEDLINE | ID: mdl-7536652

Subject(s)

Microsomes, Liver/metabolism; Tacrolimus/metabolism; Animals; Antibodies, Monoclonal; Antibody Specificity; Chromatography, High Pressure Liquid; Cross Reactions; Dexamethasone/pharmacology; Immunosuppressive Agents/metabolism; Immunosuppressive Agents/pharmacology; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver/drug effects; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Tacrolimus/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Tacrolimus Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 1995 Document type: Article Affiliation country: Japan Country of publication: United States

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