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Primary biliary cirrhosis is associated with specific changes in liver IgG-bearing cell subpopulations.
Torgano, G; Vecchi, M; Podda, M; Zuin, M; Arosio, E; Battezzati, P M; de Franchis, R.
Affiliation
  • Torgano G; Department of Internal Medicine, Ospedale Policlinico, Milano, Italy.
J Hepatol ; 22(5): 545-50, 1995 May.
Article in En | MEDLINE | ID: mdl-7650335
BACKGROUND/AIMS: The density of total IgG-bearing cells and the distribution of their subclasses were studied in the liver of patients with primary biliary cirrhosis. METHODS: Immunohistochemistry and computerized image analysis were used to compare liver specimens from 18 patients with primary biliary cirrhosis and 28 with chronic hepatitis of different etiology. RESULTS: The density of total IgG-bearing cells was similar in the two groups. However, in patients with primary biliary cirrhosis the proportion of IgG3-positive cells was significantly higher than in patients with chronic hepatitis (53 +/- 7% vs. 7.5 +/- 2.4%) (p < 10(-8)). Conversely, IgG1-positive cells were significantly less prevalent in patients with primary biliary cirrhosis than in chronic hepatitis patients (27 +/- 6.9% vs. 68 +/- 7.2%, p < 10(-8)). Stratification of patients with primary biliary cirrhosis according to histology did not show any difference in the distribution of IgG subclasses associated with the progression of disease. CONCLUSION: These data suggest a pathogenetic role of local IgG3-bearing cells in primary biliary cirrhosis.
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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Liver / Liver Cirrhosis, Biliary Type of study: Observational_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 1995 Document type: Article Affiliation country: Italy Country of publication: Netherlands
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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Liver / Liver Cirrhosis, Biliary Type of study: Observational_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 1995 Document type: Article Affiliation country: Italy Country of publication: Netherlands