Growth hormone signaling leading to CYP2C12 gene expression in rat hepatocytes involves phospholipase A2.

Tollet, P; Hamberg, M; Gustafsson, J A; Mode, A

Tollet, P; Hamberg, M; Gustafsson, J A; Mode, A.

Affiliation

Tollet P; Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden.

J Biol Chem ; 270(21): 12569-77, 1995 May 26.

Article in En | MEDLINE | ID: mdl-7759504

Subject(s)

Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System/biosynthesis; Gene Expression Regulation; Growth Hormone/pharmacology; Liver/drug effects; Phospholipases A/metabolism; Signal Transduction/physiology; Steroid Hydroxylases/biosynthesis; 5,8,11,14-Eicosatetraynoic Acid/pharmacology; Animals; Arachidonic Acid/metabolism; Benzoquinones; Calcimycin/pharmacology; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Cytochrome P-450 Enzyme System/genetics; Diglycerides/biosynthesis; Enzyme Activation; Insulin-Like Growth Factor I/biosynthesis; Insulin-Like Growth Factor I/genetics; Ketoconazole/pharmacology; Lactams, Macrocyclic; Liver/cytology; Phospholipases A2; Phospholipids/metabolism; Phosphorylation; Proadifen/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Quinacrine/pharmacology; Quinones/pharmacology; RNA, Messenger/analysis; Rats; Rats, Sprague-Dawley; Rifabutin/analogs & derivatives; Steroid Hydroxylases/genetics; Verapamil/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipases A / Steroid Hydroxylases / Growth Hormone / Aryl Hydrocarbon Hydroxylases / Signal Transduction / Gene Expression Regulation / Cytochrome P-450 Enzyme System / Liver Limits: Animals Language: En Journal: J Biol Chem Year: 1995 Document type: Article Affiliation country: Sweden Country of publication: United States

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