Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives.

Tanizawa, A; Kohn, K W; Kohlhagen, G; Leteurtre, F; Pommier, Y

Tanizawa, A; Kohn, K W; Kohlhagen, G; Leteurtre, F; Pommier, Y.

Affiliation

Tanizawa A; Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Biochemistry ; 34(21): 7200-6, 1995 May 30.

Article in En | MEDLINE | ID: mdl-7766631

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Camptothecin/analogs & derivatives; Topoisomerase I Inhibitors; Base Sequence; Camptothecin/pharmacology; DNA; DNA Topoisomerases, Type I/metabolism; Enzyme Stability; Hydrolysis; Molecular Sequence Data; Osmolar Concentration; Salts

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Collection: 01-internacional Database: MEDLINE Main subject: Camptothecin / Topoisomerase I Inhibitors / Antineoplastic Agents, Phytogenic Language: En Journal: Biochemistry Year: 1995 Document type: Article Affiliation country: United States

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