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Laboratory induced resistance to praziquantel in experimental schistosomiasis.
Ismail, M M; Taha, S A; Farghaly, A M; el-Azony, A S.
Affiliation
  • Ismail MM; Department of Parasitology, Faculty of Medicine, Zagazig University, Egypt.
J Egypt Soc Parasitol ; 24(3): 685-95, 1994 Dec.
Article in En | MEDLINE | ID: mdl-7844435
To study the effect of praziquantel (PZQ) on successive generations of S. mansoni worms, infected mice were treated 6 weeks after infection with different doses of PZQ (300, 500 mg/kg.), the schistosome strain was originally obtained from an infected Egyptian patient. The eggs subsequently produced by worms that had survived the PZQ treatment were used to infect snails and mice of the following generations. The results were expressed as average number of worms and cure rates in comparison with control groups. It was found that the use of PZQ., especially in low subcurative dose may lead to the development of resistance to therapeutic dose of the drug in following generations.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Praziquantel / Schistosoma mansoni / Schistosomiasis mansoni Limits: Animals Language: En Journal: J Egypt Soc Parasitol Year: 1994 Document type: Article Affiliation country: Egypt Country of publication: Egypt
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Collection: 01-internacional Database: MEDLINE Main subject: Praziquantel / Schistosoma mansoni / Schistosomiasis mansoni Limits: Animals Language: En Journal: J Egypt Soc Parasitol Year: 1994 Document type: Article Affiliation country: Egypt Country of publication: Egypt