Brain metabolite changes on in vivo proton magnetic resonance spectroscopy in children with congenital hypothyroidism.
J Pediatr
; 126(3): 389-92, 1995 Mar.
Article
in En
| MEDLINE
| ID: mdl-7869198
Localized in vivo proton magnetic resonance spectroscopy and imaging were performed in five children with untreated congenital hypothyroidism to look for biochemical markers of abnormal myelin and neuronal development. The patients had high levels of choline-containing compounds, which returned to normal with euthyroidism. These metabolic alterations may reflect blocks in myelin maturation that are reversible by thyroid hormone replacement throughout childhood.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Magnetic Resonance Spectroscopy
/
Congenital Hypothyroidism
/
Hypothyroidism
Limits:
Adolescent
/
Child
/
Humans
Language:
En
Journal:
J Pediatr
Year:
1995
Document type:
Article
Affiliation country:
India
Country of publication:
United States