Mutant cell lines unresponsive to alpha/beta and gamma interferon are defective in tyrosine phosphorylation of ISGF-3 alpha components.

Loh, J E; Schindler, C; Ziemiecki, A; Harpur, A G; Wilks, A F; Flavell, R A

Loh, J E; Schindler, C; Ziemiecki, A; Harpur, A G; Wilks, A F; Flavell, R A.

Affiliation

Loh JE; Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510.

Mol Cell Biol ; 14(3): 2170-9, 1994 Mar.

Article in En | MEDLINE | ID: mdl-8114747

Subject(s)

DNA-Binding Proteins/metabolism; Interferon Type I/pharmacology; Interferon-gamma/pharmacology; Phosphoproteins/metabolism; Proto-Oncogene Proteins; Transcription Factors/metabolism; Blotting, Western; Cell Compartmentation; DNA-Binding Proteins/chemistry; Fluorescent Antibody Technique; Gene Expression Regulation; Genetic Complementation Test; HeLa Cells; Humans; In Vitro Techniques; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Janus Kinase 2; Molecular Weight; Phosphoproteins/chemistry; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Protein-Tyrosine Kinases/physiology; Proteins/metabolism; RNA, Messenger/genetics; Signal Transduction; TYK2 Kinase; Transcription Factors/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Transcription Factors / Interferon Type I / Proto-Oncogene Proteins / Interferon-gamma / DNA-Binding Proteins Limits: Humans Language: En Journal: Mol Cell Biol Year: 1994 Document type: Article Country of publication: United States

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