Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis.

Xie, D L; Hui, F; Meyers, R; Homandberg, G A

Xie, D L; Hui, F; Meyers, R; Homandberg, G A.

Affiliation

Xie DL; Department of Biochemistry, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612-3864.

Arch Biochem Biophys ; 311(2): 205-12, 1994 Jun.

Article in En | MEDLINE | ID: mdl-8203882

Subject(s)

Cartilage, Articular/metabolism; Fibronectins/pharmacology; Metalloendopeptidases/metabolism; Peptide Fragments/pharmacology; Proteoglycans/biosynthesis; Serine Endopeptidases/metabolism; Synovial Fluid/physiology; Animals; Blotting, Western; Cartilage, Articular/drug effects; Cartilage, Articular/enzymology; Cattle; Cells, Cultured; Cysteine/metabolism; Enzyme Activation; Gelatinases/metabolism; Humans; Insulin-Like Growth Factor I/pharmacology; Interferon-gamma/pharmacology; Kinetics; Matrix Metalloproteinase 3; Methionine/metabolism; Proteoglycans/analysis; Recombinant Proteins/pharmacology; Sulfur Radioisotopes; Time Factors; Transforming Growth Factor beta/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Proteoglycans / Synovial Fluid / Metalloendopeptidases / Serine Endopeptidases / Cartilage, Articular / Fibronectins Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Arch Biochem Biophys Year: 1994 Document type: Article Country of publication: United States

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