Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation.

Faraci, W S; Zorn, S H; Bakker, A V; Jackson, E; Pratt, K

Faraci, W S; Zorn, S H; Bakker, A V; Jackson, E; Pratt, K.

Affiliation

Faraci WS; Central Research Division, Pfizer Inc., Groton, CT 06340.

Biochem J ; 291 ( Pt 2): 369-74, 1993 Apr 15.

Article in En | MEDLINE | ID: mdl-8387266

Subject(s)

Beryllium/pharmacology; Brain/enzymology; Inositol Phosphates/metabolism; Lithium/pharmacology; Phosphoric Monoester Hydrolases/antagonists & inhibitors; Animals; Binding, Competitive; Cattle; Humans; Hydrolysis; Inositol/metabolism; Kinetics; Neuroblastoma/enzymology; Rats; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beryllium / Brain / Phosphoric Monoester Hydrolases / Inositol Phosphates / Lithium Limits: Animals / Humans Language: En Journal: Biochem J Year: 1993 Document type: Article Country of publication: United kingdom

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