HIV-1 and immunological changes during pregnancy: a comparison between HIV-1-seropositive and HIV-1-seronegative women in Nairobi, Kenya.
AIDS
; 9(9): 1057-60, 1995 Sep.
Article
in En
| MEDLINE
| ID: mdl-8527078
ABSTRACT
PIP: The impact of HIV-1 on pregnancy was investigated in a prospective case-control study of 416 pregnant HIV-infected women and 407 age- and parity-matched pregnant HIV-seronegative women from Nairobi, Kenya. No relationship existed between gestational age (14-30 weeks) and any hematologic or immunologic variable studied. In both cases and controls, the CD4 percentage (but not absolute count) was lower postpartum than during pregnancy, while CD8 absolute counts and percentages were significantly higher in the postpartum period. The differences between HIV-positive and HIV-negative women in changes during pregnancy in CD4 and CD8 cells and their ratio were not statistically significant. These findings fail to provide support for a synergistic effect of HIV-1 and pregnancy on immune function. Further studies are needed, however, to assess the long-term effects of pregnancy in HIV-infected women, to determine the impact of pregnancy at different stages of HIV disease, and to establish normal and HIV-1-related T-lymphocyte subset profiles during the entire course of pregnancy in African women.
Key words
Acquired Immunodeficiency Syndrome; Africa; Africa South Of The Sahara; Biology; Case Control Studies; Clinical Research; Cytologic Effects; Demographic Factors; Developing Countries; Diseases; Eastern Africa; English Speaking Africa; Hiv Infections; Immunity; Immunologic Factors; Kenya; Physiology; Population; Population Characteristics; Pregnancy; Pregnant Women; Reproduction; Research Methodology; Research Report; Studies; Viral Diseases
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Urban Population
/
HIV-1
/
HIV Seropositivity
/
HIV Seronegativity
/
Developing Countries
Type of study:
Observational_studies
Aspects:
Determinantes_sociais_saude
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Africa
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
1995
Document type:
Article
Affiliation country:
Belgium
Country of publication:
United kingdom