Ionophore properties of monensin derivatives studied on human erythrocytes by 23Na NMR and K+ and H+ potentiometry: relationship with antimicrobial and antimalarial activities.

Rochdi, M; Delort, A M; Guyot, J; Sancelme, M; Gibot, S; Gourcy, J G; Dauphin, G; Gumila, C; Vial, H; Jeminet, G

Rochdi, M; Delort, A M; Guyot, J; Sancelme, M; Gibot, S; Gourcy, J G; Dauphin, G; Gumila, C; Vial, H; Jeminet, G.

Affiliation

Rochdi M; Université Blaise Pascal, U.R.A. 485 du C.N.R.S., Laboratoire de Synthèse et Etude de Systèmes à Intérêt Biologique, Aubière, France.

J Med Chem ; 39(2): 588-95, 1996 Jan 19.

Article in En | MEDLINE | ID: mdl-8558531

Subject(s)

Anti-Infective Agents/pharmacology; Antimalarials/pharmacology; Erythrocytes/drug effects; Hydrogen/metabolism; Ionophores/pharmacology; Monensin/pharmacology; Potassium/metabolism; Adult; Animals; Anti-Bacterial Agents; Anti-Infective Agents/chemistry; Antimalarials/chemistry; Candida albicans/drug effects; Erythrocytes/metabolism; Gram-Positive Bacteria/drug effects; Humans; Hydrogen-Ion Concentration; Ion Transport; Ionophores/chemistry; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Monensin/chemistry; Plasmodium falciparum/drug effects; Potentiometry; Sodium Isotopes; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Monensin / Erythrocytes / Hydrogen / Ionophores / Anti-Infective Agents / Antimalarials Limits: Adult / Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Document type: Article Affiliation country: France

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