Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides.

Stewart, A J; Canitrot, Y; Baracchini, E; Dean, N M; Deeley, R G; Cole, S P

Stewart, A J; Canitrot, Y; Baracchini, E; Dean, N M; Deeley, R G; Cole, S P.

Affiliation

Stewart AJ; Cancer Research Laboratories, Queen's University, Kingston, Ontario, Canada.

Biochem Pharmacol ; 51(4): 461-9, 1996 Feb 23.

Article in En | MEDLINE | ID: mdl-8619891

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis; Drug Resistance, Multiple/genetics; Gene Expression Regulation, Neoplastic/drug effects; Oligonucleotides, Antisense/pharmacology; ATP Binding Cassette Transporter, Subfamily B, Member 1/analysis; ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; Base Sequence; Carcinoma, Small Cell; Cell Survival/drug effects; Doxorubicin/toxicity; Enzyme-Linked Immunosorbent Assay; HeLa Cells; Humans; Lung Neoplasms; Molecular Sequence Data; RNA, Messenger/analysis; RNA, Messenger/biosynthesis; Recombinant Proteins/biosynthesis; Structure-Activity Relationship; Thionucleotides; Transfection; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Oligonucleotides, Antisense / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Drug Resistance, Multiple Limits: Humans Language: En Journal: Biochem Pharmacol Year: 1996 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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