Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes.

Ginès, P; Li, X; Brown, S E; Nakamura, T; Guzelian, P S; Heasley, L E; Schrier, R W; Nemenoff, R A

Ginès, P; Li, X; Brown, S E; Nakamura, T; Guzelian, P S; Heasley, L E; Schrier, R W; Nemenoff, R A.

Affiliation

Ginès P; Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver 80262, USA.

Hepatology ; 23(5): 1167-73, 1996 May.

Article in En | MEDLINE | ID: mdl-8621150

Subject(s)

Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Cyclic AMP/physiology; Epidermal Growth Factor/pharmacology; Liver/drug effects; Pertussis Toxin; Virulence Factors, Bordetella/pharmacology; Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors; Cells, Cultured; Enzyme Activation; Hepatocyte Growth Factor/pharmacology; Liver/cytology; Liver/enzymology; Male; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley; ras Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Virulence Factors, Bordetella / Calcium-Calmodulin-Dependent Protein Kinases / Cyclic AMP / Pertussis Toxin / Epidermal Growth Factor / Liver Limits: Animals Language: En Journal: Hepatology Year: 1996 Document type: Article Affiliation country: United States Country of publication: United States

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