Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

Briscoe, J; Rogers, N C; Witthuhn, B A; Watling, D; Harpur, A G; Wilks, A F; Stark, G R; Ihle, J N; Kerr, I M

Briscoe, J; Rogers, N C; Witthuhn, B A; Watling, D; Harpur, A G; Wilks, A F; Stark, G R; Ihle, J N; Kerr, I M.

Affiliation

Briscoe J; Imperial Cancer Research Fund, London, UK.

EMBO J ; 15(4): 799-809, 1996 Feb 15.

Article in En | MEDLINE | ID: mdl-8631301

Subject(s)

Interferon-gamma/physiology; Protein-Tyrosine Kinases/physiology; Proto-Oncogene Proteins; Viral Interference; Animals; Antigens, CD/metabolism; Base Sequence; DNA-Binding Proteins/metabolism; Gene Expression Regulation, Enzymologic; Genes, fos; Humans; Interferon-alpha/physiology; Interleukin-6/physiology; Janus Kinase 1; Janus Kinase 2; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides/chemistry; Phosphorylation; Point Mutation; Receptors, Interferon/metabolism; Regulatory Sequences, Nucleic Acid; STAT1 Transcription Factor; Signal Transduction; Structure-Activity Relationship; Trans-Activators/metabolism; Interferon gamma Receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Interference / Protein-Tyrosine Kinases / Proto-Oncogene Proteins / Interferon-gamma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EMBO J Year: 1996 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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