Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies.

Schönleben-Janas, A; Kirsch, P; Mittl, P R; Schirmer, R H; Krauth-Siegel, R L

Schönleben-Janas, A; Kirsch, P; Mittl, P R; Schirmer, R H; Krauth-Siegel, R L.

Affiliation

Schönleben-Janas A; Institut für Biochemie II der Universität, Im Neuenheimer Feld, Heidelberg, Germany.

J Med Chem ; 39(7): 1549-54, 1996 Mar 29.

Article in En | MEDLINE | ID: mdl-8691487

Subject(s)

Flavins/pharmacology; Glutathione Reductase/antagonists & inhibitors; Antimalarials/chemistry; Antimalarials/pharmacology; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Binding Sites; Crystallography, X-Ray; Electrochemistry; Flavins/chemistry; Glutathione/metabolism; Glutathione Reductase/chemistry; Glutathione Reductase/metabolism; Humans; Kinetics; Molecular Structure; NADP/metabolism; Oxidation-Reduction; Protein Binding; Spectrometry, Fluorescence; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Flavins / Glutathione Reductase Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Document type: Article Affiliation country: Germany Country of publication: United States

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