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Cervical fetal fibronectin in patients at increased risk for preterm delivery.
Bittar, R E; Yamasaki, A A; Sasaki, S; Zugaib, M.
Affiliation
  • Bittar RE; Obstetric Clinic, University of Säo Paulo Medical School, Brazil.
Am J Obstet Gynecol ; 175(1): 178-81, 1996 Jul.
Article in En | MEDLINE | ID: mdl-8694047
ABSTRACT
PIP: Researchers evaluated the comparative effectiveness of measuring fetal fibronectin concentrations in cervical secretions by either a rapid immunoassay or an enzyme-linked immunosorbent assay as a tool for the screening of premature delivery in otherwise asymptomatic pregnant women at high risk for prematurity. Cervical secretion samples from the ectocervix were taken every two weeks between the 24th and the 34th week of pregnancy from 102 pregnant women at high risk for premature delivery. The samples were obtained with two swabs. One sample was used for the immediate-reading membrane test while the other was used for the immunoenzyme test. There was a 37.25% rate of preterm birth. Membrane tests yielded a 73.68% sensitivity and a 92.18% specificity, with a positive predictive value of 84.84% and a negative predictive value of 85.50%. The enzyme-linked immunosorbent assays were 78.94% sensitive and 85.93% specific, with a positive predictive value of 76.92% and a negative predictive value of 87.30%. The two tests were concordant with each other. There was a mean of 2.9 weeks between the last sampling and the occurrence of preterm birth. The rapid result membrane test is comparable to the standard fetal fibronectin enzyme-linked immunosorbent assays for the detection of fetal fibronectin in cervical secretions between the 24th and the 34th weeks of pregnancy.
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Collection: 01-internacional Database: MEDLINE Main subject: Cervix Uteri / Fibronectins / Fetal Proteins / Obstetric Labor, Premature Type of study: Etiology_studies / Prognostic_studies Limits: Female / Humans / Newborn / Pregnancy Language: En Journal: Am J Obstet Gynecol Year: 1996 Document type: Article Affiliation country: Brazil Country of publication: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Cervix Uteri / Fibronectins / Fetal Proteins / Obstetric Labor, Premature Type of study: Etiology_studies / Prognostic_studies Limits: Female / Humans / Newborn / Pregnancy Language: En Journal: Am J Obstet Gynecol Year: 1996 Document type: Article Affiliation country: Brazil Country of publication: United States