The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.

Xia, K; Mukhopadhyay, N K; Inhorn, R C; Barber, D L; Rose, P E; Lee, R S; Narsimhan, R P; D'Andrea, A D; Griffin, J D; Roberts, T M

Xia, K; Mukhopadhyay, N K; Inhorn, R C; Barber, D L; Rose, P E; Lee, R S; Narsimhan, R P; D'Andrea, A D; Griffin, J D; Roberts, T M.

Affiliation

Xia K; Dana-Farber Cancer Institute, Boston, MA, USA.

Proc Natl Acad Sci U S A ; 93(21): 11681-6, 1996 Oct 15.

Article in En | MEDLINE | ID: mdl-8876196

Subject(s)

Cytokines/pharmacology; Mitogen-Activated Protein Kinase Kinases; Protein Serine-Threonine Kinases/metabolism; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins p21(ras)/metabolism; Proto-Oncogene Proteins/metabolism; Animals; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Cell Line; Enzyme Activation; Erythropoietin/pharmacology; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; HeLa Cells; Humans; Interferon-gamma/pharmacology; Interleukin-2/pharmacology; Janus Kinase 2; MAP Kinase Kinase 1; Protein Serine-Threonine Kinases/isolation & purification; Protein-Tyrosine Kinases/isolation & purification; Proto-Oncogene Proteins/isolation & purification; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras)/isolation & purification; Recombinant Proteins/pharmacology; Signal Transduction; Spodoptera; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Cytokines / Proto-Oncogene Proteins p21(ras) / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Mitogen-Activated Protein Kinase Kinases Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 1996 Document type: Article Affiliation country: United States

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