Autoantibodies in leprosy sera.
Clin Rheumatol
; 15(1): 26-8, 1996 Jan.
Article
in En
| MEDLINE
| ID: mdl-8929771
Our objective was to assess the prevalence of autoantibodies in patients with leprosy. Forty-one cases of lepromatous leprosy were studied. For the detection of autoantibodies we used the Elisa technique using the following purified antigens in an Elisa assay: dsDNA, ssDNA, histone, mitochondria, RNA, RNP, SS-A, SS-B, Sm, Scl-70, Anca C, Anca P and the cardiolipin complex. As a "cut off" point we used values shown on previous studies to differentiate normal from elevated values. Antibodies to SS-B, mitochondria and cardiolipin were the most prevalent in our study. Antimitochondrial antibodies distinct from those seen in primary biliary cirrhosis and antiphospholipid antibodies with variable ligand activity to B2GIP are frequent in the sera of leprosy patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoantibodies
/
Leprosy
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Rheumatol
Year:
1996
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Germany