Targeting of the Sp1 binding sites of HIV-1 long terminal repeat with chromomycin. Disruption of nuclear factor.DNA complexes and inhibition of in vitro transcription.

Bianchi, N; Passadore, M; Rutigliano, C; Feriotto, G; Mischiati, C; Gambari, R

Bianchi, N; Passadore, M; Rutigliano, C; Feriotto, G; Mischiati, C; Gambari, R.

Affiliation

Bianchi N; Biotechnology Centre, Ferrara University, Italy.

Biochem Pharmacol ; 52(10): 1489-98, 1996 Nov 22.

Article in En | MEDLINE | ID: mdl-8937462

Subject(s)

Chromomycins/metabolism; HIV Long Terminal Repeat; HIV-1/genetics; HIV-1/metabolism; Nucleic Acid Synthesis Inhibitors/metabolism; Sp1 Transcription Factor/metabolism; Base Sequence; Binding Sites/genetics; Chromomycins/pharmacology; DNA/genetics; DNA/metabolism; DNA Footprinting; DNA Primers/genetics; HIV-1/drug effects; HeLa Cells; Humans; In Vitro Techniques; Jurkat Cells; Nuclear Proteins/metabolism; Nucleic Acid Synthesis Inhibitors/pharmacology; Polymerase Chain Reaction; Transcription, Genetic/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Chromomycins / HIV Long Terminal Repeat / Sp1 Transcription Factor / HIV-1 / Nucleic Acid Synthesis Inhibitors Limits: Humans Language: En Journal: Biochem Pharmacol Year: 1996 Document type: Article Affiliation country: Italy

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