Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease.

Riddell, D R; Graham, A; Owen, J S

Riddell, D R; Graham, A; Owen, J S.

Affiliation

Riddell DR; University Department of Medicine, Royal Free Hospital School of Medicine, London, United Kingdom.

J Biol Chem ; 272(1): 89-95, 1997 Jan 03.

Article in En | MEDLINE | ID: mdl-8995232

Subject(s)

Apolipoproteins E/pharmacology; Arginine/physiology; Platelet Aggregation Inhibitors; Platelet Aggregation/drug effects; 1-Methyl-3-isobutylxanthine/pharmacology; Blood Platelets/enzymology; Cholesterol/metabolism; Cyclic AMP/blood; Cyclic GMP/blood; Dimyristoylphosphatidylcholine; Enzyme Inhibitors/pharmacology; Guanylate Cyclase/antagonists & inhibitors; Humans; Lipoproteins, HDL/pharmacology; Membrane Lipids/metabolism; Nitric Oxide/physiology; Nitric Oxide Synthase/blood; Oxadiazoles/pharmacology; Phosphodiesterase Inhibitors/pharmacology; Quinoxalines/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Arginine / Platelet Aggregation Inhibitors / Platelet Aggregation Limits: Humans Language: En Journal: J Biol Chem Year: 1997 Document type: Article Affiliation country: United kingdom Country of publication: United States

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