The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling.

Huang, H S; Nagane, M; Klingbeil, C K; Lin, H; Nishikawa, R; Ji, X D; Huang, C M; Gill, G N; Wiley, H S; Cavenee, W K

Huang, H S; Nagane, M; Klingbeil, C K; Lin, H; Nishikawa, R; Ji, X D; Huang, C M; Gill, G N; Wiley, H S; Cavenee, W K.

Affiliation

Huang HS; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093-0660, USA. hhuang@ucsd.edu

J Biol Chem ; 272(5): 2927-35, 1997 Jan 31.

Article in En | MEDLINE | ID: mdl-9006938

Subject(s)

Brain Neoplasms/pathology; ErbB Receptors/biosynthesis; ErbB Receptors/genetics; ErbB Receptors/metabolism; Glioblastoma/pathology; Phosphotyrosine; Signal Transduction; Amino Acid Sequence; Animals; Base Sequence; Brain Neoplasms/genetics; Cell Line; DNA Primers; Down-Regulation; Endocytosis; Epidermal Growth Factor/pharmacology; ErbB Receptors/physiology; Glioblastoma/genetics; Humans; Mice; Mice, Nude; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments/chemistry; Phosphorylation; Recombinant Proteins/biosynthesis; Recombinant Proteins/metabolism; Transfection; Transplantation, Heterologous

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Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Signal Transduction / Glioblastoma / Phosphotyrosine / ErbB Receptors Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 1997 Document type: Article Affiliation country: United States Country of publication: United States

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