The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599.

Hill-Venning, C; Peters, J A; Callachan, H; Lambert, J J; Gemmell, D K; Anderson, A; Byford, A; Hamilton, N; Hill, D R; Marshall, R J; Campbell, A C

Hill-Venning, C; Peters, J A; Callachan, H; Lambert, J J; Gemmell, D K; Anderson, A; Byford, A; Hamilton, N; Hill, D R; Marshall, R J; Campbell, A C.

Affiliation

Hill-Venning C; Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, U.K.

Neuropharmacology ; 35(9-10): 1209-22, 1996.

Article in En | MEDLINE | ID: mdl-9014136

Subject(s)

Anesthetics/pharmacology; GABA Modulators/pharmacology; Pregnanediones; Pregnanolone/analogs & derivatives; Receptors, GABA-A/metabolism; Anesthetics/chemistry; Animals; Binding, Competitive/drug effects; Cattle; Chromaffin Cells/drug effects; Chromaffin Cells/metabolism; Electrophysiology; GABA Modulators/chemistry; Humans; In Vitro Techniques; Male; Membranes/drug effects; Membranes/metabolism; Mice; Mice, Inbred Strains; Neurons/drug effects; Neurons/metabolism; Pregnanolone/chemistry; Pregnanolone/pharmacology; RNA/isolation & purification; RNA/metabolism; Rats; Rats, Sprague-Dawley; Receptors, GABA-A/biosynthesis; Receptors, GABA-A/drug effects; Solubility; Transcription, Genetic; Xenopus laevis

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Collection: 01-internacional Database: MEDLINE Main subject: Pregnanediones / Pregnanolone / Receptors, GABA-A / GABA Modulators / Anesthetics Limits: Animals / Humans / Male Language: En Journal: Neuropharmacology Year: 1996 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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