Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration.

Hessel, E M; Van Oosterhout, A J; Van Ark, I; Van Esch, B; Hofman, G; Van Loveren, H; Savelkoul, H F; Nijkamp, F P

Hessel, E M; Van Oosterhout, A J; Van Ark, I; Van Esch, B; Hofman, G; Van Loveren, H; Savelkoul, H F; Nijkamp, F P.

Affiliation

Hessel EM; Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands.

Am J Respir Cell Mol Biol ; 16(3): 325-34, 1997 Mar.

Article in En | MEDLINE | ID: mdl-9070618

Subject(s)

Asthma/physiopathology; Bronchial Hyperreactivity/immunology; Eosinophils/immunology; Interferon-gamma/physiology; Administration, Inhalation; Aerosols; Animals; Antibodies, Monoclonal; Antigens/administration & dosage; Antigens/immunology; Asthma/immunology; Bronchoalveolar Lavage Fluid/immunology; Bronchoconstrictor Agents/pharmacology; Cytokines/physiology; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils/enzymology; Lung/enzymology; Male; Methacholine Chloride/pharmacology; Mice; Mice, Inbred BALB C; Ovalbumin/administration & dosage; Ovalbumin/immunology; Peroxidases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Interferon-gamma / Bronchial Hyperreactivity / Eosinophils Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 1997 Document type: Article Affiliation country: Netherlands Country of publication: United States

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