Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells.

Sandhu, C; Garbe, J; Bhattacharya, N; Daksis, J; Pan, C H; Yaswen, P; Koh, J; Slingerland, J M; Stampfer, M R

Sandhu, C; Garbe, J; Bhattacharya, N; Daksis, J; Pan, C H; Yaswen, P; Koh, J; Slingerland, J M; Stampfer, M R.

Affiliation

Sandhu C; Division of Cancer Biology Research, Toronto-Sunnybrook Regional Cancer Centre, Ontario, Canada.

Mol Cell Biol ; 17(5): 2458-67, 1997 May.

Article in En | MEDLINE | ID: mdl-9111314

Subject(s)

Breast/metabolism; CDC2-CDC28 Kinases; Carrier Proteins/metabolism; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases/metabolism; Cyclins/metabolism; Enzyme Inhibitors/pharmacology; Genes, Tumor Suppressor; Oncogene Proteins/metabolism; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Transforming Growth Factor beta/metabolism; Tumor Suppressor Proteins; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p15; Female; Flow Cytometry; Humans; Macromolecular Substances; Phosphorylation; Protein Serine-Threonine Kinases/metabolism; Resting Phase, Cell Cycle

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast / Carrier Proteins / Genes, Tumor Suppressor / Transforming Growth Factor beta / Proto-Oncogene Proteins / Oncogene Proteins / Cyclins / Cyclin-Dependent Kinases / Cell Cycle Proteins / Cyclin-Dependent Kinase Inhibitor p16 Type of study: Risk_factors_studies Limits: Female / Humans Language: En Journal: Mol Cell Biol Year: 1997 Document type: Article Affiliation country: Canada Country of publication: United States

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