High T cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes.

Honeyman, M C; Stone, N; de Aizpurua, H; Rowley, M J; Harrison, L C

Honeyman, M C; Stone, N; de Aizpurua, H; Rowley, M J; Harrison, L C.

Affiliation

Honeyman MC; The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Parkville, Victoria, Australia.

J Autoimmun ; 10(2): 165-73, 1997 Apr.

Article in En | MEDLINE | ID: mdl-9185878

Subject(s)

Diabetes Mellitus, Type 1/enzymology; Diabetes Mellitus, Type 1/immunology; Glutamate Decarboxylase/immunology; Isoenzymes/immunology; Lymphocyte Activation; T-Lymphocytes/immunology; Adolescent; Adult; Autoantibodies/biosynthesis; Autoantibodies/immunology; Autoantigens; Child; Diabetes Mellitus, Type 1/etiology; Disease Progression; HLA Antigens/genetics; Humans; Insulin/immunology; Islets of Langerhans/immunology; Longitudinal Studies; Membrane Proteins/immunology; Middle Aged; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases/immunology; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Tetanus Toxoid/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / T-Lymphocytes / Diabetes Mellitus, Type 1 / Glutamate Decarboxylase / Isoenzymes Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Humans / Middle aged Language: En Journal: J Autoimmun Journal subject: ALERGIA E IMUNOLOGIA Year: 1997 Document type: Article Affiliation country: Australia

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