O6-methylguanine-DNA methyltransferase activity in human buccal mucosal tissue and cell cultures. Complex mixtures related to habitual use of tobacco and betel quid inhibit the activity in vitro.

Liu, Y; Egyhazi, S; Hansson, J; Bhide, S V; Kulkarni, P S; Grafström, R C

Liu, Y; Egyhazi, S; Hansson, J; Bhide, S V; Kulkarni, P S; Grafström, R C.

Affiliation

Liu Y; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Carcinogenesis ; 18(10): 1889-95, 1997 Oct.

Article in En | MEDLINE | ID: mdl-9363996

Subject(s)

Mouth Mucosa/enzymology; O(6)-Methylguanine-DNA Methyltransferase/metabolism; Areca/chemistry; Areca/toxicity; Carcinoma, Squamous Cell/enzymology; Cell Line; Humans; Mouth Neoplasms/enzymology; O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors; O(6)-Methylguanine-DNA Methyltransferase/genetics; Plant Extracts/toxicity; Plants, Medicinal; Plants, Toxic; RNA, Messenger/analysis; Nicotiana/chemistry; Nicotiana/toxicity; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: O(6)-Methylguanine-DNA Methyltransferase / Mouth Mucosa Limits: Humans Language: En Journal: Carcinogenesis Year: 1997 Document type: Article Affiliation country: Sweden Country of publication: United kingdom

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