Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

Rozwarski, D A; Grant, G A; Barton, D H; Jacobs, W R; Sacchettini, J C

Rozwarski, D A; Grant, G A; Barton, D H; Jacobs, W R; Sacchettini, J C.

Affiliation

Rozwarski DA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

Science ; 279(5347): 98-102, 1998 Jan 02.

Article in En | MEDLINE | ID: mdl-9417034

Subject(s)

Antitubercular Agents/pharmacology; Isoniazid/pharmacology; Mycobacterium tuberculosis/drug effects; NAD/metabolism; Oxidoreductases/antagonists & inhibitors; Antitubercular Agents/metabolism; Bacterial Proteins; Binding Sites; Biotransformation; Crystallography, X-Ray; Drug Resistance, Microbial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acid Synthases/antagonists & inhibitors; Fatty Acid Synthases/chemistry; Fatty Acid Synthases/genetics; Fatty Acid Synthases/metabolism; Isoniazid/metabolism; Mass Spectrometry; Models, Molecular; Mutation; Mycobacterium tuberculosis/enzymology; Mycolic Acids/metabolism; NAD/chemistry; Oxidoreductases/chemistry; Oxidoreductases/genetics; Oxidoreductases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Isoniazid / Mycobacterium tuberculosis / NAD / Antitubercular Agents Language: En Journal: Science Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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