6 alpha-Fluoro- and 6 alpha,9 alpha-difluoro-11 beta,21-dihydroxy-16 alpha,17 alpha-propylmethylenedioxypregn-4-ene-3,20-dione: synthesis and evaluation of activity and kinetics of their C-22 epimers.

Thalén, B A; Axelsson, B I; Andersson, P H; Brattsand, R L; Nylander, B; Wickström, L I

Thalén, B A; Axelsson, B I; Andersson, P H; Brattsand, R L; Nylander, B; Wickström, L I.

Affiliation

Thalén BA; Department of Medicinal Chemistry, Astra Draco AB, Lund, Sweden.

Steroids ; 63(1): 37-43, 1998 Jan.

Article in En | MEDLINE | ID: mdl-9437793

Subject(s)

Diflucortolone/analogs & derivatives; Glucocorticoids/chemical synthesis; Glucocorticoids/pharmacokinetics; Animals; Biotransformation; Cytosol/metabolism; Diflucortolone/chemical synthesis; Diflucortolone/pharmacokinetics; Diflucortolone/pharmacology; Glucocorticoids/pharmacology; Humans; Male; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid/drug effects; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Diflucortolone / Glucocorticoids Limits: Animals / Humans / Male Language: En Journal: Steroids Year: 1998 Document type: Article Affiliation country: Sweden

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