Relationship between hepatic cytochrome P450 3A content and activity and the disposition of midazolam administered orally.

Wandel, C; Böcker, R H; Böhrer, H; deVries, J X; Hofmann, W; Walter, K; Kleingeist, B; Neff, S; Ding, R; Walter-Sack, I; Martin, E

Wandel, C; Böcker, R H; Böhrer, H; deVries, J X; Hofmann, W; Walter, K; Kleingeist, B; Neff, S; Ding, R; Walter-Sack, I; Martin, E.

Affiliation

Wandel C; Department of Anesthesia, Friedrich-Alexander-University.

Drug Metab Dispos ; 26(2): 110-4, 1998 Feb.

Article in En | MEDLINE | ID: mdl-9456296

Subject(s)

Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System/metabolism; Inactivation, Metabolic/physiology; Liver Neoplasms/metabolism; Microsomes, Liver/metabolism; Midazolam/administration & dosage; Oxidoreductases, N-Demethylating/metabolism; Adult; Aged; Cytochrome P-450 CYP3A; Female; Humans; Hydroxylation; Kinetics; Male; Microsomes, Liver/enzymology; Midazolam/blood; Middle Aged; White People

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Midazolam / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Inactivation, Metabolic / Cytochrome P-450 Enzyme System / Liver Neoplasms Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 1998 Document type: Article Country of publication: United States

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