Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes.

Howell, S R; Shirley, M A; Ulm, E H

Howell, S R; Shirley, M A; Ulm, E H.

Affiliation

Howell SR; Department of Drug Safety and Disposition, Ligand Pharmaceuticals, Inc., San Diego, CA 92121, USA.

Drug Metab Dispos ; 26(3): 234-9, 1998 Mar.

Article in En | MEDLINE | ID: mdl-9492386

Subject(s)

Cytochrome P-450 Enzyme System/physiology; Microsomes, Liver/drug effects; Retinoids/pharmacology; Animals; Bexarotene; Cytochrome P-450 Enzyme System/analysis; Isoenzymes/analysis; Isoenzymes/physiology; Male; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Molecular Structure; Nicotinic Acids/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Retinoic Acid/agonists; Receptors, Retinoic Acid/metabolism; Retinoid X Receptors; Tetrahydronaphthalenes/pharmacology; Transcription Factors/agonists; Transcription Factors/metabolism; Tretinoin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Retinoids / Microsomes, Liver / Cytochrome P-450 Enzyme System Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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