Endothelial dysfunction in streptozotocin-diabetic rats is not reversed by dietary probucol or simvastatin supplementation.

Palmer, A M; Gopaul, N; Dhir, S; Thomas, C R; Poston, L; Tribe, R M

Palmer, A M; Gopaul, N; Dhir, S; Thomas, C R; Poston, L; Tribe, R M.

Affiliation

Palmer AM; Division of Obstetrics and Gynaecology, United Medical and Dental Schools, St Thomas' Hospital, London, UK.

Diabetologia ; 41(2): 157-64, 1998 Feb.

Article in En | MEDLINE | ID: mdl-9498648

Subject(s)

Antioxidants/pharmacology; Diabetes Mellitus, Experimental/physiopathology; Endothelium, Vascular/drug effects; Hypolipidemic Agents/pharmacology; Probucol/pharmacology; Simvastatin/pharmacology; Animals; Antioxidants/administration & dosage; Blood Glucose/metabolism; Body Weight/drug effects; Diabetes Mellitus, Experimental/blood; Diabetes Mellitus, Experimental/metabolism; Diet; Dinoprost/analogs & derivatives; Dinoprost/blood; Dinoprost/metabolism; Eating/drug effects; Endothelium, Vascular/physiopathology; F2-Isoprostanes; Hypolipidemic Agents/administration & dosage; Lipid Peroxidation/drug effects; Lipids/blood; Male; Mesenteric Arteries/drug effects; Mesenteric Arteries/physiopathology; Muscle Relaxation/drug effects; Oxidative Stress/drug effects; Probucol/administration & dosage; Probucol/blood; Probucol/metabolism; Rats; Rats, Sprague-Dawley; Simvastatin/administration & dosage; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Probucol / Endothelium, Vascular / Simvastatin / Diabetes Mellitus, Experimental / Hypolipidemic Agents / Antioxidants Limits: Animals Language: En Journal: Diabetologia Year: 1998 Document type: Article Affiliation country: United kingdom Country of publication: Germany

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