Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.

Mitchell, R; McCulloch, D; Lutz, E; Johnson, M; MacKenzie, C; Fennell, M; Fink, G; Zhou, W; Sealfon, S C

Mitchell, R; McCulloch, D; Lutz, E; Johnson, M; MacKenzie, C; Fennell, M; Fink, G; Zhou, W; Sealfon, S C.

Affiliation

Mitchell R; MRC Brain Metabolism Unit, Edinburgh, UK. rmitchell@srv1.bmu.mrc.ac.uk

Nature ; 392(6674): 411-4, 1998 Mar 26.

Article in En | MEDLINE | ID: mdl-9537328

Subject(s)

GTP-Binding Proteins/metabolism; Phospholipase D/metabolism; Receptors, LHRH/metabolism; Receptors, Muscarinic/metabolism; Rhodopsin/metabolism; ADP-Ribosylation Factors; Animals; Brefeldin A; COS Cells; Cyclopentanes/pharmacology; Enzyme Activation; Estrenes/pharmacology; GTP-Binding Proteins/antagonists & inhibitors; Guanosine Triphosphate/analogs & derivatives; Guanosine Triphosphate/metabolism; Humans; Male; Phospholipase D/antagonists & inhibitors; Pyrrolidinones/pharmacology; Rats; Receptor, Muscarinic M3; Receptors, LHRH/agonists; Receptors, LHRH/chemistry; Receptors, LHRH/genetics; Receptors, Muscarinic/chemistry; Recombinant Proteins/metabolism; Rhodopsin/chemistry; Tumor Cells, Cultured; Type C Phospholipases/antagonists & inhibitors; Type C Phospholipases/metabolism; rhoA GTP-Binding Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipase D / Rhodopsin / Receptors, Muscarinic / Receptors, LHRH / GTP-Binding Proteins Type of study: Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Nature Year: 1998 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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