Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas.

Tsuruzoe, K; Araki, E; Furukawa, N; Shirotani, T; Matsumoto, K; Kaneko, K; Motoshima, H; Yoshizato, K; Shirakami, A; Kishikawa, H; Miyazaki, J; Shichiri, M

Tsuruzoe, K; Araki, E; Furukawa, N; Shirotani, T; Matsumoto, K; Kaneko, K; Motoshima, H; Yoshizato, K; Shirakami, A; Kishikawa, H; Miyazaki, J; Shichiri, M.

Affiliation

Tsuruzoe K; Department of Metabolic Medicine, Kumamoto University School of Medicine, Honjo, Japan.

Diabetes ; 47(4): 621-31, 1998 Apr.

Article in En | MEDLINE | ID: mdl-9568696

Subject(s)

DNA, Mitochondrial/biosynthesis; Glucose/pharmacology; Insulin/metabolism; Islets of Langerhans/metabolism; Leucine/pharmacology; Sulfonylurea Compounds/pharmacology; Adenosine Triphosphate/biosynthesis; Calcium/metabolism; Cell Respiration; Ethidium/pharmacology; Glucose/metabolism; Histocytochemistry; Humans; Insulin/biosynthesis; Insulin/genetics; Insulin Secretion; Intracellular Fluid/metabolism; Islets of Langerhans/cytology; Mitochondria/enzymology; Oxidation-Reduction; Phosphorylation; RNA, Messenger/biosynthesis; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonylurea Compounds / DNA, Mitochondrial / Islets of Langerhans / Glucose / Insulin / Leucine Limits: Humans Language: En Journal: Diabetes Year: 1998 Document type: Article Affiliation country: Japan Country of publication: United States

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