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Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.
Zimmermann, C R; Johnson, S M; Martens, G W; White, A G; Zimmer, B L; Pappagianis, D.
Affiliation
  • Zimmermann CR; Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis 95616, USA. crzimmermann@ucdavis.edu
Infect Immun ; 66(5): 2342-5, 1998 May.
Article in En | MEDLINE | ID: mdl-9573127
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fungal Vaccines / Coccidioides / Coccidioidomycosis Limits: Animals Language: En Journal: Infect Immun Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fungal Vaccines / Coccidioides / Coccidioidomycosis Limits: Animals Language: En Journal: Infect Immun Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States