Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.

Beirith, A; Santos, A R; Rodrigues, A L; Creczynski-Pasa, T B; Calixto, J B

Beirith, A; Santos, A R; Rodrigues, A L; Creczynski-Pasa, T B; Calixto, J B.

Affiliation

Beirith A; Department of Pharmacology, Centre of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

Eur J Pharmacol ; 345(3): 233-45, 1998 Mar 26.

Article in En | MEDLINE | ID: mdl-9592021

Subject(s)

Analgesics, Non-Narcotic/pharmacology; Dipyrone/pharmacology; Pain Measurement/drug effects; Spinal Cord/drug effects; Analgesics, Non-Narcotic/administration & dosage; Animals; Capsaicin; Dipyrone/administration & dosage; Enzyme Inhibitors/pharmacology; Formaldehyde; Glutamic Acid/metabolism; Hyperalgesia/chemically induced; Hyperalgesia/drug therapy; Male; Mice; Nitric Oxide Synthase/antagonists & inhibitors; Nitric Oxide Synthase Type I; Pain/chemically induced; Pain/drug therapy; Postural Balance/drug effects; Psychomotor Performance/drug effects; Rats; Rats, Wistar; Reaction Time/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Pain Measurement / Dipyrone / Analgesics, Non-Narcotic Limits: Animals Language: En Journal: Eur J Pharmacol Year: 1998 Document type: Article Affiliation country: Brazil Country of publication: Netherlands

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